A Fascinating Insight into Gender Differences in Cannabis Therapy
Explore the surprising differences in cannabis treatment between men and women. From the symptoms that lead each to seek treatment, through differing body structures, to hormonal influences — are we truly considering these varying effects?
In recent years, cannabis has become an effective therapeutic tool for a wide range of medical conditions. However, significant differences have emerged in how cannabis affects men and women.
This article will review common symptoms prompting cannabis treatment for each gender, examine differences in body structure and cannabinoid receptor locations, and explore the impact of various hormones on cannabis absorption and effects.
Ready for the treatment?
Different Challenges: Common Symptoms in Women and Men
Women and men turn to cannabis treatment for diverse reasons. Among women, common reasons include chronic pain, migraines, premenstrual syndrome (PMS), and sleep disorders. Many women also use cannabis to alleviate menopause symptoms, such as hot flashes and mood swings. Additionally, women often report relief from anxiety and depression symptoms after cannabis use.
Research by Dr. Carrie Cuttler from Washington State University in 2018 indicates that 64.1% of women in her study used cannabis for medical purposes, compared to 54.3% of men.
Conversely, men primarily seek cannabis treatment for muscle and joint pain, recurring injuries, and inflammation. Men are also more likely to use cannabis for sleep disorders and PTSD. Some men find cannabis beneficial for improving appetite and relieving symptoms of chronic conditions like Crohn’s disease and rheumatoid arthritis.
Data show that men generally use cannabis more frequently and in larger quantities than women. According to Dr. Cuttler's research, 73.4% of men in Washington State, where cannabis is legal for recreational use, consume it for leisure, compared to 65.5% of women. Additionally, women are more likely to start using cannabis after age 30, indicating a more measured and moderate approach compared to men.
Different Body Structures, Different Absorption
Recent advancements in medical cannabis research have allowed for a better understanding of gender differences in cannabinoid responses. Research by Tiziana Rubino and Daniela Parolaro from the University of Insubria in Italy highlights the significant impact of body structure on cannabinoid absorption and metabolism.
The differing body structures and biochemical differences between men and women affect how cannabinoids are absorbed and utilized biologically. Generally, women experience different absorption and metabolic processes in the endocannabinoid system compared to men. Studies indicate that women have higher levels of active THC metabolites, the therapeutic and psychoactive component of cannabis.
Differences in body structure also influence how cannabis is absorbed and acts. Cannabinoid receptors, known as CB1 and CB2, are located differently in male and female bodies, affecting treatment efficacy and potential responses. For example, women have higher concentrations of cannabinoid receptors in brain areas related to pain and hormone regulation. This may explain why women report more significant relief from pain and mental distress symptoms after cannabis treatment.
Additionally, higher cannabinoid receptor concentrations in the female immune system can affect their response to treatment for inflammatory diseases. In contrast, men have higher concentrations of cannabinoid receptors in the peripheral nervous system, potentially providing unique benefits in localized pain management.
Hormones? Cannabis Impact on Estrogen and Estradiol
Research by Dickie Struik, Fabrizio Sanna, and Liana Lattore from the University of Cagliari in Italy indicates that cannabis can significantly influence estrogen hormones, particularly estradiol. These hormones play a central role in the reproductive system and in molecular adaptations to various physiological and psychological factors.
Women experience dynamic hormonal fluctuations in a cyclical pattern. During the menstrual cycle, levels of estrogen, progesterone, and estradiol vary, peaking during ovulation and declining at other times. These changes affect the nervous system's absorption of active cannabis components, influencing functions such as mood, appetite, pain perception, and memory.
For instance, hormonal impacts on enzymes responsible for breaking down cannabinoid components can alter the digestion and absorption rates of cannabis, leading to varying effects depending on the menstrual cycle stage.
Additional research shows that cannabinoid receptor levels in the brain increase with age in women, revealing molecular changes at different life stages. This suggests the endocannabinoid system may become more sensitive or active with age in response to changes in estradiol levels.
These findings are crucial for understanding gender differences in cannabis use and effects. Since hormonal fluctuations can affect cannabis sensitivity, women may experience different effects depending on their menstrual cycle stage or age. These hormonal changes can also influence study outcomes related to cannabis use and treatment processes.
Conclusion: Understanding Differences and Tailoring Treatment
In conclusion, there are significant differences between men and women in cannabis treatment. Variations in symptoms, body structure, cannabinoid receptors, and hormonal influences underscore the need for personalized cannabis treatment. Recognizing these differences can help patients and healthcare providers choose the most appropriate dosage and method for using cannabis products, ensuring more effective and safer treatment.
Comments